Advocate Spot-On Solution for Large Dogs 10-25kg 2.5mlAdvocate Spot On Solution for Large Dogs 10 25kg 2. 5ml Advocate Spot On Solution for Large Dogs is a broad spectrum combined flea and worm treatment for dogs weighing between 10 25kg that are suffering from, or at risk from, mixed parasitic infections. Advocate contains Imidacloprid and Moxidectin as the active ingredients, which are effective against fleas, flea larvae, roundworms, hookworms, whipworms, sarcoptic mange, ear mites and Demodex mites.