POLA Wrinkle Shot Medical Serum N 20g | Japan's First MHLW-Approved Anti-Wrinkle SerumPOLA Wrinkle Shot Medical Serum N Japan's First MHLW Approved Anti Wrinkle Serum POLA Wrinkle Shot Medical Serum N is the renewed flagship of POLA's prestige anti aging line. It is a quasi drug (), meaning it carries Japan's Ministry of Health, Labour and Welfare (MHLW) authorization for the claim "improves wrinkles" POLA was the first brand in Japan to receive this approval. The active ingredient NEI L1 is a proprietary triple complex that targets