Plague and the End of Antiquity: The Pandemic of 541-750Plague was a key factor in the waning of Antiquity and the beginning of the Middle Ages. Eight centuries before the Black Death, a pandemic of plague engulfed the lands surrounding the Mediterranean Sea and eventually extended as far east as Persia and as far north as the British Isles. Its persisted sporadically from 541 to 750, the same period that witnessed the distinctive shaping of the Byzantine Empire, a new prominence of the Roman papacy and of